JDSE
Journal of Dental Sciences and Education

The Journal of Dental Sciences and Education deals with General Dentistry, Pediatric Dentistry, Restorative Dentistry, Orthodontics, Oral diagnosis and DentomaxilloFacial Radiology, Endodontics, Prosthetic Dentistry, Periodontology, Oral and Maxillofacial Surgery, Oral Implantology, Dental Education and other dentistry fields and accepts articles on these topics. Journal of Dental Science and Education publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements.

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Diabetes and periodontitis: current approach
Abstract
Diabetes is described as a systemic disease that manifests itself with many major complications that determine the quality of life. The chronic complications of diabetes have been defined as macro- and microvascular complications. In recent years, periodontitis has also been identified as one of these complications. Diabetes negatively affects oral and dental/gum health. Metabolic disorders in diabetic patients reduce the resistance of gum tissues to infection, thereby increasing the likelihood of gum disease. Impairment of oral and dental/gum health also disrupts blood sugar regulation in diabetic patients. Thus, the negative effect is two-way. The relationship between periodontitis and diabetes has also been observed in many studies. The aim of this study is to provide information about diabetes and periodontitis, explain the relationship between diabetes and periodontitis, and offer the best possible dental care and counseling to diabetic patients based on general dental knowledge.

Keywords : Diabetes, oral health, dental health, periodontitis

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1. TEMD Diabetes Mellitus ve Komplikasyonlarının Tanı, Tedavi ve İzlem Kılavuzu-2024, https://file.temd.org.tr/Uploads/publications/guides/documents/diabetesmellitus2024.pdf, erişim tarihi 26.06.2024.
2. American Diabetes Association Professional Practice Committee; 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024. Diabetes Care. 2024;47(Suppl_1):S20-S42. doi:10.2337/dc24-S002
3. Sanz M, Ceriello A, Buysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract. 2018;137:231-241. doi:10.1016/j.diabres.2017.12.001
4. Satman I, Omer B, Tutuncu Y, et al; TURDEP-II Study Group. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol. 2013;28(2):169-180. doi:10.1007/s10654-013-9771-5
5. Tosun N, Satman İ, Erkoç Y, et al. Turkiye Diyabet Önleme ve Kontrol Programı Eylem Planı 2011-2014. Ankara: Anıl Matbaası, 2011, pp.134.
6. Gojka R. WHO Global report on diabetes: a summary. Int J Noncommunicable Dis. 2016. doi:10.4103/ 2468-8827.184853
7. Kolaric V, Svircevic V, Bijuk R, Zupancic V. Chronic complications of diabetes and quality of life. Acta Clin Croat. 2022;61(3):520-527. doi:10.20471/acc.2022.61.03.18
8. Kocher T, König J, Borgnakke WS, Pink C, Meisel P. Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge. Periodontol 2000. 2018;78(1):59-97. doi:10.1111/prd.12235
9. Stöhr J, Barbaresko J, Neuenschwander M, Schlesinger S. Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies. Sci Rep. 2021; 11(1):13686. doi:10.1038/s41598-021-93062-6
10. Kesici H. Diyabet ve periodontitis. KSU Tıp Fak Derg. 2016;11(3):23-25.
11. Miller WD. The human mouth as a focus of infection. Lancet. 1891; 138(3546):340-342.
12. Billings F. Focal infection: its broader application in the etiology of general disease. J Am Med Assoc. 1914;63(11):899-903.
13. Beck JD, Papapanou PN, Philips KH, Offenbacher S. Periodontal medicine: 100 years of progress. J Dent Res. 2019;98(10):1053-1062. doi: 10.1177/0022034519846113
14. Williams RC, Offenbacher S. Periodontal medicine: the emergence of a new branch of periodontology. Periodontol 2000. 2000;23:9-12. doi:10. 1034/j.1600-0757.2000.2230101.x
15. Taylor GW, Burt BA, Becker MP, et al. Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. J Periodontol. 1998;69(1):76-83. doi:10.1902/jop.1998.69.1.76
16. Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(Suppl 1):S173-S182. doi:10.1002/JPER.17-0721
17. Turner C. Diabetes mellitus and periodontal disease: a new perspective. Prim Dent J. 2024;13(2):73-78. doi: 10.1177/20501684241254654
18. Aydogan T, Karsiyaka Hendek M, Unsal B, et al. Effects of D3K2 with periodontal therapy in diabetes mellitus and stage I-II periodontitis patients. Oral Dis. 2025;31(2):640-647. doi:10.1111/odi.15147
19. Higham J, Scannapieco FA. Epidemiological associations between periodontitis and cancer. Periodontol 2000. 2024;96(1):74-82. doi:10. 1111/prd.12599
20. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615-1625. doi:10.2337/diabetes.54.6. 1615
21. Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidemiol. 2000;151(3):273-282. doi:10.1093/oxfordjournals.aje.a010203
22. Saremi A, Nelson RG, Tulloch-Reidn M, et al. Periodontal disease and mortality in type 2 diabetes. Diabetes Care. 2005;28(1):27-32. doi:10. 2337/diacare.28.1.27
23. Thorstensson H, Kuylenstiema J, Hugoson A. Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. J Clin Periodontol. 1996;23(3):194-202. doi: 10. 1111/j.1600-051x.1996.tb02076.x
24. Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Periodontol. 2018; 89(Suppl 1):S1-S8. doi:10.1002/JPER.18-0157
25. Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000. 2001;25:8-20. doi:10.1034/j.1600-0757.2001.22250102.x
26. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159-S172. doi:10.1002/JPER.18-0006. Erratum in: J Periodontol. 2018;89(12):1475. doi:10.1002/jper.10239
27. Axelsson P, Lindhe J, Nyström B. On the prevention of caries and periodontal disease. Results of a 15-year longitudinal study in adults. J Clin Periodontol. 1991;18(3):182-189. doi:10.1111/j.1600-051x.1991.tb01131.x
28. Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol. 2014;35(1): 3-11. doi:10.1016/j.it.2013.09.001
29. Lindhe J, Socransky SS, Nyman S, Haffajee A, Westfelt E. “Critical probing depths” in periodontal therapy. J Clin Periodontol. 1982;9(4):323-36. doi:10.1111/j.1600-051x.1982.tb02099.x
30. Apatzidou DA, Kinane DF. Nonsurgical mechanical treatment strategies for periodontal disease. Dent Clin North Am. 2010;54(1):1-12. doi:10.1016/j.cden.2009.08.006
31. Cobb CM. Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Pperiodontol. 2002;29:22-32.
32. Haas AN, Furlaneto F, Gaio EJ, et al. New tendencies in non-surgical periodontal therapy. Braz Oral Res. 2021;35(Supp 2):e095. doi:10.1590/ 1807-3107bor-2021.vol35.0095
33. Sun Y, Yin Y, Yang S, et al. Lipotoxicity: The missing link between diabetes and periodontitis? J Periodontal Res. 2024;59(3):431-445. doi: 10.1111/jre.13242
34. Tang H, Zhou Y, Ma L, et al. SIRT3 alleviates mitochondrial dysfunction and senescence in diabetes-associated periodontitis by deacetylating LRPPRC. Free Radic Biol Med. 2025;227:407-419. doi:10.1016/j.freeradbiomed.2024.11.033
35. Li S, Li S, Meng L, Gao R, Liu H, Li M. Immunopathogenesis and immunotherapy of diabetes-associated periodontitis. Clin Oral Investig. 2025;29(1):44. doi:10.1007/s00784-024-06141-z
36. Li L, Qin W, Ye T, et al. Bioactive Zn-V-Si-Ca glass nanoparticle hydrogel microneedles with antimicrobial and antioxidant properties for bone regeneration in diabetic periodontitis. ACS Nano. 2025;19(8):7981-7995. doi:10.1021/acsnano.4c15227
37. Zou M, Yang J. Identify novel therapeutic targets for type II diabetes and periodontitis: insights from single-cell analysis and Mendelian randomization analysis. Front Endocrinol (Lausanne). 2024;15:1410537. doi:10.3389/fendo.2024.1410537
Article available in :
Volume 3, Issue 2, 2025
Page : 35-41
https://doi.org/10.51271/JDSE-0053
Article Information
Received : 01 May 2025
Accepted : 29 May 2025
Published : 31 May 2025
Corresponding Author :

Tolga Aydoğan: Department of Periodontology, Ankara Topraklık Oral and Dental Health Center, Ankara, Turkiye

[email protected]
Citation : Aydoğan T, Çifci A. Diabetes and periodontitis: current approach. J Dent Sci Educ. 2025;3(2):35-41.

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