The Journal of Dental Sciences and Education deals with General Dentistry, Pediatric Dentistry, Restorative Dentistry, Orthodontics, Oral diagnosis and DentomaxilloFacial Radiology, Endodontics, Prosthetic Dentistry, Periodontology, Oral and Maxillofacial Surgery, Oral Implantology, Dental Education and other dentistry fields and accepts articles on these topics. Journal of Dental Science and Education publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Dental caries and demineralization in head and neck cancer patients undergoing radiotherapy
The number of head and neck cancer (HNC) patients is steadily increasing, and the use of radiotherapy for treatment in this patient group has been associated with side effects such as mucositis, trismus, xerostomia, dental caries, periodontal disease, and osteoradionecrosis (ORN). Radiation caries (RC) can be atypical, and their treatment can be challenging. Preventing and treating RC become crucial as post-radiotherapy tooth extraction can pave the way for ORN. The aim of this review is to evaluate the restorative dental treatment for HNC patients before, during, and after radiotherapy. This includes examining the impact of radiotherapy on tooth decay and demineralization, and providing solutions to address these effects.

1. Paleri V, Roland N. Introduction to the United Kingdom nationalmultidisciplinary guidelines for head and neck cancer. J Laryngol Otol.2016;130(S2):S3-S4.
2. Kawashita Y, Soutome S, Umeda M, Saito T. Oral managementstrategies for radiotherapy of head and neck cancer. Jpn Dent Sci Rev.2020;56(1):62-67.
3. Argiris A, Eng C. Epidemiology, staging, and screening of head andneck cancer. Cancer Treat Res. 2003;114:15-60.
4. Chow LQM. Head and neck cancer. N Engl J Med. 2020;382:60-72.
5. Fitzmaurice C, Allen C, Barber RM, et al. Global, regional, and nationalcancer incidence, mortality, years of life lost, years lived with disability,and disability-adjusted lifeyears for 32 cancer groups, 1990 to 2015.JAMA Oncol. 2017;3(4):524-548.
6. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A.Global cancer statistics 2018: GLOBOCAN estimates of incidence andmortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin.2018;68(6):394-424.
7. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020:GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249.
8. De Felice F, Polimeni A, Valentini V et al. Radiotherapy controversiesand prospective in head and neck cancer: a literature-based criticalreview. Neoplasia. 2018;20(3):227-232.
9. Specht L. Oral complications in the head and neck radiationpatient. Introduction and scope of the problem. Supp Care Cancer.2002;10(1):36-39.
10. Jham B C, da Silva Freire AR. Oral complications of radiotherapy in thehead and neck. Braz J Otorhinolaryngol. 2006;72(5):704-708.
11. Shah JP, Gil Z. Current concepts in management of oral cancer-surgery.Oral Oncol. 2009;45(4-5):394-401.
12. Lin SS, Massa ST, Varvares MA. Improved overall survival andmortality in head and neck cancer with adjuvant concurrentchemoradiotherapy in national databases. Head Neck. 2016;38(2)208-215.
13. Gupta N, Pal M, Rawat S, et al. Radiation-induced dental caries,prevention and treatment- a systematic review. Natl J Maxillofac Surg.2015;6(2):160-166.
14. Naidu MUR, Ramana GV, Rani PU, Mohan Iyyapu K, Suman A,Roy P. Chemotherapy-induced and/or radiation therapy-inducedoral mucositis-complicating the treatment of cancer. Neoplasia.2004;6(5):423-431.
15. Bensadoun RJ, Riesenbeck D, Lockhart PB, et al. A systematic review oftrismus induced by cancer therapies in head and neck cancer patients.Support Care Cancer. 2010;18(8):1033-1038.
16. Jensen SB, Pedersen AML, Vissink A, et al. A systematic reviewof salivary gland hypofunction and xerostomia induced by cancertherapies: prevalence, severity and impact on quality of life. SupportCare Cancer. 2010;18(8):1039-1060.
17. Hong CH, Napeñas JJ, Hodgson BD, et al. A systematic review of dentaldisease in patients undergoing cancer therapy. Support Care Cancer.2010;18(8):1007-1021.
18. Epstein JB, Stevenson-Moore P. Periodontal disease and periodontalmanagement in patients with cancer. Oral Oncol. 2001;37(8):613-619.
19. Nabil S, Samman N. Incidence and prevention of osteoradionecrosisafter dental extraction in irradiated patients: a systematic review. Int JOral Maxillofac Surg. 2011;40(3):229-243.
20. Jawad H, Hodson NA, Nixon PJ. A review of dental treatment of headand neck cancer patients, before, during and after radiotherapy: part 1.Br Dent J. 2015;218(2):65-68.
21. Begg AC, Stewart FA, Vens C. Strategies to improve radiotherapy withtargeted drugs. Nat Rev Cancer. 2011;11(4):239-253.
22. Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy:current advances and future directions. Int J Med Sci. 2012;9(3):193-199.
23. Wolff A, Joshi RK, Ekström J, et al. A guide to medications inducingsalivary gland dysfunction, xerostomia, and subjective sialorrhea: asystematic review sponsored by the world workshop on oral medicineVI. Drugs R&D. 2017;17(1):1-28.
24. Mercadante S, Aielli F, Adile C, et al. Prevalence of oral mucositis,dry mouth, and dysphagia in advanced cancer patients. Support CareCancer. 2015;23(11):3249-3255.
25. Buzalaf MAR, Ortiz AC, Carvalho TS, et al. Saliva as a diagnostic toolfor dental caries, periodontal disease and cancer: is there a need formore biomarkers? Expert Rev Mol Diagn. 2020;20(5):543-555.
26. Papale F, Santonocito S, Polizzi A, et al. The new era of salivaomics indentistry: frontiers and facts in the early diagnosis and prevention oforal diseases and cancer. Metabolites. 2022;12(7):638.
27. Chiappin S, Antonelli G, Gatti R, Elio F. Saliva specimen: a newlaboratory tool for diagnostic and basic investigation. Clin Chim Acta.2007;383(1-2):30-40.
28. Ruhl S. The scientific exploration of saliva in the post-proteomicera: from database back to basic function. Expert Rev Proteomics.2012;9(1):85-96.
29. Podzimek S, Vondrackova L, Duskova J, Janatova T, Broukal Z.Salivary markers for periodontal and general diseases. Dis Markers.2016;9179632.
30. Kaczor-Urbanowicz KE, Martin Carreras-Presas C, Aro K, et al.Saliva diagnostics - current views and directions. Exp Biol Med.2017;242(5):459-472.
31. Vistoso Monreal A, Polonsky G, Shiboski C, Sankar V, Villa A. Salivarygland dysfunction secondary to cancer treatment. Front Oral Health.2022;3:907778.
32. Dawes C, Pedersen AM, Villa A, et al. The functions of human saliva:a review sponsored by the world workshop on oral medicine VI. ArchOral Biol. 2015;60(6):863-874.
33. Mercadante V, Al Hamad A, Lodi G, Porter S, Fedele S. Interventions forthe management of radiotherapy-induced xerostomia and hyposalivation:a systematic review and meta-analysis. Oral Oncol. 2017;66:64-74.
34. Levine N. Outfitting your practice for safety and efficiency. Dent ProdRep. 2020;54:41-44.
35. Hegde M, Bhat R, Punja A, Shetty C. Correlation between dental cariesand salivary albumin in adult Indian population—an in vivo study. Br JMed Med Res. 2014;4(25):4238-4244.
36. Lalla RV, Latortue MC, Hong CH, et al. A systematic review of oralfungal infections in patients receiving cancer therapy. Support CareCancer. 2010;18(8):985-992.
37. Brosky ME. The role of saliva in oral health: strategies for preventionand management of xerostomia. J Support Oncol. 2007;5(5):215-225.
38. Da Silva JD, Mitchell DA, Mitchell L. Oxford American Handbook ofClinical Dentistry (Oxford American Handbooks of Medicine). OxfordUniversity Press: 2007.
39. Walsh LJ. Contemporary technologies for remineralisation therapies: areview. Int Dent SA. 2009;11(6):6-16.
40. Valstar MH, de Bakker BS, Steenbakkers RJ, et al. The tubarial salivaryglands: a potential new organ at risk for radiotherapy. Radiother Oncol.2021;154:292-298.
41. Polat SÖ. Tükürük bezlerine güncel bakış: yeni bir organ tartışması.Arch Med Rev J. 2021;30(2):59-67.
42. Kilian M, Chapple IL, Hannig M, et al. The oral microbiome - anupdate for oral healthcare professionals. Br Dent J. 2016;221(10):657-666.
43. Whiteside SA, Razvi H, Dave S, Reid G, Burton JP. The microbiome ofthe urinary tract-a role beyond infection. Nat Rev Urol. 2015;12(2):81-90.
44. Willis JR, Gabaldón T. The human oral microbiome in health anddisease: from sequences to ecosystems. Microorganisms. 2020;8(2):308.
45. Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role ofthe microbiome in human development. Gut. 2019;68(6):1108-1114.
46. Deo PN, Deshmukh R. Oral microbiome: unveiling the fundamentals. JOral Maxillofac Pathol. 2019;23(1):122-128.
47. Epstein JB, Thariat J, Bensadoun RJ, et al. Oral complications of cancerand cancer therapy: from cancer treatment to survivorship. CA CancerJ Clin. 2012;62(6):400-422.
48. Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Lückel H. Radiation-related damage to dentition. Lancet Oncol. 2006;7(4):326-335.
49. Vissink A, Jansma J, Spijkervet FKL, Burlage FR, Coppes RP. Oralsequelae of head and neck radiotherapy. Crit Rev Oral Biol Med.2003;14(3):199-212.
50. Palmier NR, Ribeiro ACP, Fonsêca JM, et al. Radiation-related cariesassessment through the international caries detection and assessmentsystem and the post-radiation dental index. Oral Surg Oral Med OralPathol Oral Radiol. 2017;124(6):542-547.
51. Moore C, McLister C, Cardwell C, O’Neill C, Donnelly M, McKennaG. Dental caries following radiotherapy for head and neck cancer: asystematic review. Oral Oncol. 2020;100:104484.
52. Siala W, Mnejja W, Elloumi F, et al. Late toxicities after conventionalradiotherapy for nasopharyngeal carcinoma: incidence and risk factors.J Radiother. 2014;2014:268340.
53. Palmier NR, Migliorati CA, Prado-Ribeiro AC, et al. Radiation-relatedcaries: current diagnostic, prognostic, and management paradigms.Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;130(1):52-62.
54. Santos-Silva AR, Feio Pdo S, Vargas PA, Correa ME, Lopes MA.cGVHD-related caries and its shared features with other ‘dry-mouth’-related caries. Braz Dent J. 2015;26(4):435-440.
55. Madrid CC, Paglioni MP, Line SR, et al. Structural analysis of enamelin teeth of head-and-neck cancer patients who underwent radiotherapy.Caries Res. 2017;51(2):119-128.
56. Madrid C, Abarca M, Bouferrache K. Osteoradionecrosis: an update.Oral Oncol. 2010;46(6):471-474.
57. Irie MS, Mendes EM, Borges JS, Osuna LG, Rabelo GD, Soares PB.Periodontal therapy for patients before and after radiotherapy: a reviewof the literature and topics of interest for clinicians. Med Oral PatolOral Cir Bucal. 2018;23(5):e524-e530.
58. Schiødt M, Hermund NU. Management of oral disease prior toradiation therapy. Supp Care Cancer. 2002;10(1):40-43.
59. Lanzetti J, Finotti F, Savarino M, Gassino G, Dell’Acqua A, ErovigniFM. Management of oral hygiene in head-neck cancer patientsundergoing oncological surgery and radiotherapy: a systematic review.Dent J. 2023;11(3):83.
60. Jones JA, Chavarri-Guerra Y, Corrêa LBC, et al. MASCC/ISOO expertopinion on the management of oral problems in patients with advancedcancer. Supp Care Cancer. 2022;30(11):8761-8773.
61. McCaul LK. Oral and dental management for head and neck cancerpatients treated by chemotherapy and radiotherapy. Dent Update.2012;39(2):135-138.
62. Yokota T, Tachibana H, Konishi T, et al. Multicenter phase II study ofan oral care program for patients with head and neckcancer receivingchemoradiotherapy. Supp Care Cancer. 2016;24(7):3029-3036.
63. Turner L, Mupparapu M, Akintoye SO. Review of the complicationsassociated with treatment of oropharyngeal cancer: a guide for thedental practitioner. Quintessence Int. 2013;44(3):267-79.
64. Kumar N. The oral management of oncology patients requiringradiotherapy, chemotherapy and/or bone marrow transplantation -clinical guidelines. R Coll Surg Engl/Br Soc Disabil Oral Heal. 2019.
65. Gupta N, Pal M, Rawat S, et al. Radiation-induced dental caries,prevention and treatment - a systematic review. Natl J Maxillofac Surg.2015;6(2):160-166.
66. McComb D, Erickson RL, Maxymiw WG, Wood RE. A clinicalcomparison of glass ionomer, resinmodified glass ionomer and resincomposite restorations in the treatment of cervical caries in xerostomichead and neck radiation patients. Oper Dent. 2002;27(5):430-437.
67. De Moor RJ, Stassen IG, van’t Veldt Y, Torbeyns D, Hommez GM.Two-year clinical performance of glass ionomer and resin compositerestorations in xerostomic head and neck irradiated cancer patients.Clin Oral Investig. 2011;15(1):31-38.
68. Kalsi H, McCaul LK, Rodriguez JM. The role of primary dental carepractitioners in the long-term management of patients treated for headand neck cancer. Br Dent J. 2022;233(9):765-768.
69. Papas A, Russell D, Singh M, Kent R, Triol C, Winston A. Caries clinicaltrial of a remineralising toothpaste in radiation patients. Gerodontol.2008;25(2):76-88.
70. Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC. Newapproaches to enhanced remineralization of tooth enamel. J Dent Res.2010;89(11):1187-1197.
71. Preetha A, Banerjee R. Comparison of artificial saliva substitutes.Trends Biomaterials Artificial Organs. 2005;18(2):178-187.
72. Foglio-Bonda A, Foglio-Bonda PL, Bottini M, Pezzotti F, MigliarioM. Chemical-physical characteristics of artificial saliva substitutes:rheological evaluation. Eur Rev Med Pharmacol Sci. 2022;26(21):7833-7839.
73. Wiseman LR, Faulds D. Oral pilocarpine: a review of itspharmacological properties and clinical potential in xerostomia. Drugs.1995;49(1):143-155.
74. Ahlner BH, Hagelqvist E, Lind MG. Influence on rabbit submandibulargland injury by stimulation or inhibition of gland function duringirradiation. Histology and morphometry after 15 gray. Ann Otol RhinolLaryngol. 1994;103(2):125-134.
75. Rode M, Smid L, Budihna M, Gassperssic D, Rode M, Soba E. Theinfluence of pilocarpine and biperiden on pH value and calcium,phosphate, and bicarbonate concentrations in saliva during and afterradiotherapy for head and neck cancer. Oral Surg Oral Med Oral PatholOral Radiol Endod. 2001;92(5):509-514.
76. Brizel DM, Murphy BA, Rosenthal DI, et al. Phase II study of paliferminand concurrent chemoradiation in head and neck squamous cellcarcinoma. J Clin Oncol. 2008;26(15):2489-2496.
77. Riley P, Glenny AM, Hua F, Worthington HV. Pharmacologicalinterventions for preventing dry mouth and salivary glanddysfunction following radiotherapy. Cochrane Database Syst Rev.2017;7(7):CD012744.
Volume 2, Issue 1, 2024
Page : 24-29