The Journal of Dental Sciences and Education deals with General Dentistry, Pediatric Dentistry, Restorative Dentistry, Orthodontics, Oral diagnosis and DentomaxilloFacial Radiology, Endodontics, Prosthetic Dentistry, Periodontology, Oral and Maxillofacial Surgery, Oral Implantology, Dental Education and other dentistry fields and accepts articles on these topics. Journal of Dental Science and Education publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements.

EndNote Style
Gingival crevicular fluid and peri-implant sulcus fluid
Gingival crevicular fluid (GCF) is an important source for the assessment of periodontal and peri-implant disease activity and response to periodontal therapy. GCF contains cellular components such as epithelium, bacteria, leukocytes, erythrocytes, viruses and their by-products, electrolytes, bacterial metabolic products, host and bacterial enzymes, and enzyme inhibitors such as acid phosphatase, alkaline phosphatase, cytokines, and immunoglobulins. In addition, it is also found that drugs taken systemically pass into the GCF.

1. Buduneli N, Kinane DF. Host-derived diagnostic markers related tosoft tissue destruction and bone degradation in periodontitis. J ClinPeriodontol. 2011;38 Suppl 11:85-105.
2. Brägger U. Radiographic parameters: biological significance andclinical use. Periodontol 2000. 2005;39(1):73-90.
3. Loos BG, Tjoa S. Host-derived diagnostic markers for periodontitis: dothey exist in gingival crevice fluid? Periodontol 2000. 2005;39(1):53-72.
4. Griffiths GS. Formation, collection and significance of gingival crevicefluid. Periodontol 2000. 2003;31(1):32-42.
5. Del Fabbro M, Francetti L, Bulfamante G, et al. Fluid dynamicsof gingival tissues in transition from physiological condition toinflammation. J Periodontol. 2001;72(1):65-73.
6. Pashley DH. A mechanistic analysis of gingival fluid production. JPeriodontal Res. 1976;11(2):121-134.
7. Brito F, Curcio HFQ, da Silva Fidalgo TK. Periodontal diseasemetabolomics signatures from different biofluids: a systematic review.Metabolomics. 2022;18(11):83.
8. Baima G, Corana M, Iaderosa G, et al. Metabolomicsofgingivalcrevicularfluidto identify biomarkers for periodontitis: Asystematic review with meta-analysis. J Periodontal Res. 2021;56(4):633-645.
9. Almehmadi AH, Alghamdi F. Biomarkers of alveolar bone resorptioningingivalcrevicularfluid: A systematic review. Arch Oral Biol.2018;93:12-21.
10. Bostanci N, Belibasakis GN. Precision periodontal care: from omicsdiscoveries to chairside diagnostics. Clin Oral Investig. 2023;27(3):971-978.
11. Loe H, Holm-Pedersen P. Absence and presence of fluid from normaland inflamed gingiva. Periodontics. 1965;149:171-177.
12. Maulani C, Auerkari EI, C Masulili SL, Soeroso Y, Djoko Santoso W, SKusdhany L. Association between Epstein-Barr virus and periodontitis:A meta-analysis. PLoS One. 2021;16(10):e0258109.
13. Maticic M, Poljak M, Kramar B. Proviral HIV-1 DNA in gingivalcrevicular fluid of HIV-1- infected patients in various stages of HIVdisease. J Dent Res. 2000;79(7):1496-1501.
14. Delima AJ, Van Dyke TE. Origin and function of the cellularcomponents in gingival crevice fluid. Periodontol 2000;31(1):55-76.
15. Bartold PM, Narayanan AS. Biology of the Periodontal ConnectiveTissues Quintessence Publishing Co, Illinois-USA, 1998;223-240.
16. Phillips L,Chu L,Kolodrubetz D.Multiple enzymes can makehydrogen sulfide from cysteine in Treponema denticola. Anaerobe.2020;64:102231.
17. Lamster IB, Ahlo JK. Analysis of gingival crevicular fluid as appliedto the diagnosis of oral and systemic diseases. Ann N Y Acad Sci.2007;1098(1):216-229.
18. Prathapan Santhakumari P, Varma Raja V, Joseph J, Devaraj A, John E,Oommen Thomas N. Impact of Low-Level Laser Therapy on OrthodonticTooth Movement and VariousCytokinesinGingivalCrevicularFluid:A Split-Mouth Randomized Study. Cureus. 2023;15(8):e42809.
19. Sumbayak IA, Masulili SLC, Tadjoedin FM, et al. Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10Cytokinesin OlderPeople with Periodontitis. Geriatrics (Basel). 2023;8(4):79.
20. Oliveira JA, de Oliveira Alves R, Nascimento IM, HidalgoMAR, Scarel-Caminaga RM, Cristina Pigossi S. Pro- and anti-inflammatorycytokinesand osteoclastogenesis-related factors inperi-implant diseases: systematic review and meta-analysis. BMC OralHealth. 2023;23(1):420.
21. Peskersoy C, Oguzhan A, Gurlek O. The Effect of Flowable CompositeResins on Periodontal Health, Cytokine Levels, andImmunoglobulins.Biomed Res Int. 2022;2022:6476597.
22. Moriya Y, Obama T, Aiuchi T, et al. Quantitative proteomic analysisofgingivalcrevicularfluids from deciduous and permanent teeth. JClin Periodontol. 2017;44(4):353-362.
23. Heasman PA, Ward A, Barrett AW, Seymour RA, Edwards G.Flurbiprofen in human crevicular fluid analyzed by high-performanceliquid chromatography. J Periodontal Res. 1990;25(2):88-92.
24. Mclaughlin WS, Ball DE, Seymour RA, Kamali F, White K. Thepharmacokinetics of phenytoin in gingival crevicular fluid and plasmain relation to gingival overgrowth. J Clin Periodontol. 1995;22(12):942-945.
25. Sakellari D, Goodson JM, Socransky SS, Kolokotronis A, KonstantinidisA. Concentration of 3 tetracyclines in plasma, gingival crevice fluid andsaliva. J Clin Periodontol. 2000;27(1):53-60.
26. Björn AL, Koch G, Lindhe J. Evaluation of gingival fluid measurements.Odontol Revy. 1965;16(4):300-307.
27. Sueda T, Bang J, Cimasoni G. Collection of gingival fluid forquantitative analysis. J Dent Res. 1969;48(1):159.
28. Skapski H, Lehner T. A crevicular washing method for investigatingimmune components of crevicular fluid in man. J Periodontal Res.1976;11(1):19-24.
29. Challacombe SJ, Russell MW, Hawkes J. Passage of intact IgG fromplasma to the oral cavity via crevicular fluid. Clin Exp Immunol.1978;34(3):417-422.
30. Oppenheim FG. Preliminary observations on the presence and originof serum albumin in human saliva. Helv Odontol Acta. 1970;14(1):10-17.
31. Özkavaf A, Aras H, Huri CB. Analysis of factors that may affect theenzymatic profile of gingival crevicular fluid: Sampling technique,sequential sampling and mode of data presentation. J Oral Sci.2001;43(1):41-48.
32. Majeed ZN,PhilipK,AlabsiAM,Pushparajan S,SwaminathanD.Identification of Gingival Crevicular Fluid Sampling, AnalyticalMethods, and Oral Biomarkers for the Diagnosis and Monitoringof Periodontal Diseases: A Systematic Review. Dis Markers.2016;2016:1804727.
33. Hancock EB, Cray J, O’leary J. Relationship between gingival crevicularfluid and gingival inflammation: A clinical and histologic study. JPeriodontol. 1979;50(1):13-19
34. Caldeira FID,Hidalgo MAR,Dias MLC,Scarel-CaminagaRM,PigossiSC. Systematic review of ratios between disease /healthperiodontitis modulators and meta-analysis of their levels in gingivaltissue and biological fluids. Arch Oral Biol. 2021;127:105147.
35. Sorensen SE, Larsen IB, Jörgensen KD. Gingival and alveolar bonereaction to marginal fit of subgingival crown margins. Scand J DentRes. 1986;94(2):109-114.
36. Weinstein E, Mandel I, Salkind A, Oshrain HI, Pappas GD. Studies ofgingival fluid. Periodontics. 1967;5:161-166.
37. Ciantar M, Caruana DJ. Periotron 8000: Calibration characteristics andreliability. J Periodontal Res. 1998;33(5):259-264.
38. Hatipoğlu H. Potential Factors Which Affect Gingival Crevicular FluidSampling Procedures. EÜ Dişhek Fak Derg, 2010;31:69-81.
39. Garnick JJ, Pearson R, Harrell D. The evaluation of the Periotron. JPeriodontol. 1979;50(8):424-426.
40. LindhE J, Attstrom R, Bjorn AL. Influence of sex hormones on gingivalexudate of gingivitis-free female dogs. J Periodontal Res. 1968;3(4):273-278
41. Bissada NF, Schaffer EM, Haus E. Circadian periodicity of humancrevicular fluid. J Periodontol. 1967;38(1):36-40.
42. Nagao M. Influence of prosthetic appliances upon the flow of creviculartissue fluid. I. Relation between crevicular tissue fluid and prostheticappliances. Bull Tokyo Med Dent Univ. 1967;14:241.
43. Dutra TP,Sacramento CM,Nagay BE,et al. Do smokers have a differentgingival crevicular fluid cytokine/chemokine profile than nonsmokersin clinically healthy periodontal sites? A systematic review and meta-analysis. Clin Oral Investig. 2022;26(2):1183-1197.
44. Koidou VP,Chatzopoulos GS,Tomas I,NibaliL,Donos N.Expressionof gingival crevicular fluid markers during early and late healing ofintrabony defects after surgical treatment: a systematic review. ClinOral Investig. 2020;24(1):487-502.
45. Janska E, Mohr B, Wahl G. Correlation between peri-implant sulcularfluid rate andexpression of collagenase 2 (MMP8). Clin Oral Investig.2016;20(2):261-266.
46. Javed F, Al-Hezaimi K, Salameh Z, Almas K, Romanos GE.Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis. Cytokine. 2011;53(1):8-12.
47. Dursun E, Tözüm TF. Peri-Implant Crevicular Fluid Analysis,Enzymes and Biomarkers: a Systematic Review. J Oral Maxillofac Res.2016;7(3):e9.
Volume 1, Issue 3, 2023
Page : 98-100